Pathogenesis

Definition

Pathogenesis is the term that is used to describe the origin and development of a disease.

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Latest Research and Reviews

  • Reviews |

    This Review summarizes the latest findings on heart reverse remodelling, which demonstrate that despite apparent normalization of function, the molecular changes associated with heart failure persist in the reverse-remodelled heart. This myocardial remission is distinct from true recovery, in which both function and molecular makeup are normalized. These findings have implications for developing therapies to repair the failing heart.

    • Gene H. Kim
    • , Nir Uriel
    •  & Daniel Burkhoff
  • Research |

    Analysis of global remethylation in mouse embryos at several developmental stages identifies an epigenetic landscape that partitions extraembryonic tissues within the embryo and resembles a frequent, global departure in genome regulation in human cancers.

    • Zachary D. Smith
    • , Jiantao Shi
    • , Hongcang Gu
    • , Julie Donaghey
    • , Kendell Clement
    • , Davide Cacchiarelli
    • , Andreas Gnirke
    • , Franziska Michor
    •  & Alexander Meissner
  • Research | | open

    Deep penetrating nevi (DPN) are unusual melanocytic neoplasms with unknown genetic drivers. Here the authors show that majority of DPN harbor activating mutations in the β-catenin and the MAP-kinase pathways; this characteristic can help in the classification and grading of these distinctive neoplasms.

    • Iwei Yeh
    • , Ursula E. Lang
    • , Emeline Durieux
    • , Meng Kian Tee
    • , Aparna Jorapur
    • , A. Hunter Shain
    • , Veronique Haddad
    • , Daniel Pissaloux
    • , Xu Chen
    • , Lorenzo Cerroni
    • , Robert L. Judson
    • , Philip E. LeBoit
    • , Timothy H. McCalmont
    • , Boris C. Bastian
    •  & Arnaud de la Fouchardière
  • Research | | open

    IgE is an important mediator of protective immunity as well as allergic reaction, but how high affinity IgE antibodies are produced in memory responses is not clear. Here the authors show that IgE can be generated via class-switch recombination in IgG1 memory B cells without additional somatic hypermutation.

    • Jin-Shu He
    • , Sharrada Subramaniam
    • , Vipin Narang
    • , Kandhadayar Srinivasan
    • , Sean P. Saunders
    • , Daniel Carbajo
    • , Tsao Wen-Shan
    • , Nur Hidayah Hamadee
    • , Josephine Lum
    • , Andrea Lee
    • , Jinmiao Chen
    • , Michael Poidinger
    • , Francesca Zolezzi
    • , Juan J. Lafaille
    •  & Maria A. Curotto de Lafaille

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