Health sciences

Definition

The health sciences study all aspects of health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.

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Latest Research and Reviews

  • Reviews |

    Direct-acting antiviral agents (DAAs) are highly effective treatments for HCV, but are not always accessible to people who inject drugs (PWID). Here, Grebely and colleagues outline the epidemiology of HCV in PWID, discuss current data on DAA outcomes in this population and highlight steps required to broaden access to HCV therapy with the eventual goal of HCV elimination.

    • Jason Grebely
    • , Behzad Hajarizadeh
    •  & Gregory J. Dore
  • Research |

    Brain-region-specific RNA-seq from humans with major depressive disorder reveals unique transcriptomic profiles in males and females, with little overlap.

    • Benoit Labonté
    • , Olivia Engmann
    • , Immanuel Purushothaman
    • , Caroline Menard
    • , Junshi Wang
    • , Chunfeng Tan
    • , Joseph R Scarpa
    • , Gregory Moy
    • , Yong-Hwee E Loh
    • , Michael Cahill
    • , Zachary S Lorsch
    • , Peter J Hamilton
    • , Erin S Calipari
    • , Georgia E Hodes
    • , Orna Issler
    • , Hope Kronman
    • , Madeline Pfau
    • , Aleksandar L J Obradovic
    • , Yan Dong
    • , Rachael L Neve
    • , Scott Russo
    • , Andrew Kazarskis
    • , Carol Tamminga
    • , Naguib Mechawar
    • , Gustavo Turecki
    • , Bin Zhang
    • , Li Shen
    •  & Eric J Nestler
  • Research |

    No response by an immune cell occurs in isolation but is instead the summation of multiple interacting signals. Ivashkiv and colleagues describe the epigenetic landscape that results from the integration of the inflammatory cytokines type I interferons and TNF.

    • Sung Ho Park
    • , Kyuho Kang
    • , Eugenia Giannopoulou
    • , Yu Qiao
    • , Keunsoo Kang
    • , Geonho Kim
    • , Kyung-Hyun Park-Min
    •  & Lionel B Ivashkiv
  • Research |

    Paz Polak, Jaegil Kim, Lior Z. Braunstein and colleagues have identified patterns of genome-wide mutation in certain breast cancers that can be used to identify those with DNA-repair deficiencies that make the tumor more likely to respond to therapies based on PARP inhibitors or platinum. In contrast, oncogenic mutations in several other DNA-repair genes do not generate these patterns.

    • Paz Polak
    • , Jaegil Kim
    • , Lior Z Braunstein
    • , Rosa Karlic
    • , Nicholas J Haradhavala
    • , Grace Tiao
    • , Daniel Rosebrock
    • , Dimitri Livitz
    • , Kirsten Kübler
    • , Kent W Mouw
    • , Atanas Kamburov
    • , Yosef E Maruvka
    • , Ignaty Leshchiner
    • , Eric S Lander
    • , Todd R Golub
    • , Aviad Zick
    • , Alexandre Orthwein
    • , Michael S Lawrence
    • , Rajbir N Batra
    • , Carlos Caldas
    • , Daniel A Haber
    • , Peter W Laird
    • , Hui Shen
    • , Leif W Ellisen
    • , Alan D D'Andrea
    • , Stephen J Chanock
    • , William D Foulkes
    •  & Gad Getz
  • Research |

    Horton et al. show that early Crebbp loss in haematopoietic progenitors results in a defective p53-mediated DNA damage response, leading to the accumulation of epigenetic and genetic alterations, which promote the onset of lymphoid malignancies.

    • Sarah J. Horton
    • , George Giotopoulos
    • , Haiyang Yun
    • , Shabana Vohra
    • , Olivia Sheppard
    • , Rachael Bashford-Rogers
    • , Mamunur Rashid
    • , Alexandra Clipson
    • , Wai-In Chan
    • , Daniel Sasca
    • , Loukia Yiangou
    • , Hikari Osaki
    • , Faisal Basheer
    • , Paolo Gallipoli
    • , Natalie Burrows
    • , Ayşegül Erdem
    • , Anastasiya Sybirna
    • , Sarah Foerster
    • , Wanfeng Zhao
    • , Tonci Sustic
    • , Anna Petrunkina Harrison
    • , Elisa Laurenti
    • , Jessica Okosun
    • , Daniel Hodson
    • , Penny Wright
    • , Ken G. Smith
    • , Patrick Maxwell
    • , Jude Fitzgibbon
    • , Ming Q. Du
    • , David J. Adams
    •  & Brian J. P. Huntly

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