Developmental biology

Definition

Developmental biology is the field of biology that studies the processes by which multicellular organisms grow and develop, controlled by their genes. Knowledge of normal developmental processes can aid in the understanding of developmental abnormalities and other conditions such as cancer.

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Latest Research and Reviews

  • Research |

    Analysis of global remethylation in mouse embryos at several developmental stages identifies an epigenetic landscape that partitions extraembryonic tissues within the embryo and resembles a frequent, global departure in genome regulation in human cancers.

    • Zachary D. Smith
    • , Jiantao Shi
    • , Hongcang Gu
    • , Julie Donaghey
    • , Kendell Clement
    • , Davide Cacchiarelli
    • , Andreas Gnirke
    • , Franziska Michor
    •  & Alexander Meissner
  • Research |

    Whole-genome sequencing data of 14,688 Icelanders, including 1,548 parent–offspring trios, show how the age and sex of parents affect the rate and spectrum of de novo mutations.

    • Hákon Jónsson
    • , Patrick Sulem
    • , Birte Kehr
    • , Snaedis Kristmundsdottir
    • , Florian Zink
    • , Eirikur Hjartarson
    • , Marteinn T. Hardarson
    • , Kristjan E. Hjorleifsson
    • , Hannes P. Eggertsson
    • , Sigurjon Axel Gudjonsson
    • , Lucas D. Ward
    • , Gudny A. Arnadottir
    • , Einar A. Helgason
    • , Hannes Helgason
    • , Arnaldur Gylfason
    • , Adalbjorg Jonasdottir
    • , Aslaug Jonasdottir
    • , Thorunn Rafnar
    • , Mike Frigge
    • , Simon N. Stacey
    • , Olafur Th. Magnusson
    • , Unnur Thorsteinsdottir
    • , Gisli Masson
    • , Augustine Kong
    • , Bjarni V. Halldorsson
    • , Agnar Helgason
    • , Daniel F. Gudbjartsson
    •  & Kari Stefansson
  • Research |

    Genome editing in human zygotes shows that OCT4 is required for normal development at an earlier stage in humans than in mice.

    • Norah M. E. Fogarty
    • , Afshan McCarthy
    • , Kirsten E. Snijders
    • , Benjamin E. Powell
    • , Nada Kubikova
    • , Paul Blakeley
    • , Rebecca Lea
    • , Kay Elder
    • , Sissy E. Wamaitha
    • , Daesik Kim
    • , Valdone Maciulyte
    • , Jens Kleinjung
    • , Jin-Soo Kim
    • , Dagan Wells
    • , Ludovic Vallier
    • , Alessandro Bertero
    • , James M. A. Turner
    •  & Kathy K. Niakan
  • Research | | open

    Clarifying the source of proteins in mixed biological environments, such as after transplantation or parabiosis, remains a challenge. Here, the authors address this need with a mouse strain that incorporates a methionine derivate into proteins, allowing for their detection using click chemistry and antibody arrays.

    • Yan Liu
    • , Michael J. Conboy
    • , Melod Mehdipour
    • , Yutong Liu
    • , Thanhtra P. Tran
    • , Aaron Blotnick
    • , Prasanna Rajan
    • , Thalie Cavalcante Santos
    •  & Irina M. Conboy

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