Chemical biology

Definition

Chemical biology is the study of the chemicals and chemical reactions involved in biological processes, incorporating the disciplines of bioorganic chemistry, biochemistry, cell biology and pharmacology. Chemicals – including natural small molecules, such as lipids, carbohydrates and metals, or non-natural probe or drug molecules – are used to gain insight into biological problems at a mechanistic level.

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Latest Research and Reviews

  • Reviews |

    Neuroscience is going nanoscopic, but can it still rely on classical electrophysiology? In this Review, Savtchenko, Poo and Rusakov argue that accurate interpretation of physiological observations on the nanoscale must account for electrodiffusion phenomena arising from local perturbations of ionic concentrations.

    • Leonid P. Savtchenko
    • , Mu Ming Poo
    •  & Dmitri A. Rusakov
  • Research |

    The biosynthesis of secondary metabolites such as stephacidin A and its congeners continues to intrigue both biochemists and synthetic chemists. Now, a laboratory chemical synthesis of these natural products has been achieved based on a bioinspired synthetic strategy, which may provide key insights into the possible biosynthesis of these captivating molecules.

    • Ken Mukai
    • , Danilo Pereira de Sant'Ana
    • , Yasuo Hirooka
    • , Eduardo V. Mercado-Marin
    • , David E. Stephens
    • , Kevin G. M. Kou
    • , Sven C. Richter
    • , Naomi Kelley
    •  & Richmond Sarpong
  • Research |

    The N6-methyladenosine (m6A) modification in mRNAs, generated by the enzyme METTL3, controls normal human hematopoietic stem/progenitor cell differentiation and maintains the undifferentiated leukemic phenotype of human acute myeloid leukemia cells.

    • Ly P Vu
    • , Brian F Pickering
    • , Yuanming Cheng
    • , Sara Zaccara
    • , Diu Nguyen
    • , Gerard Minuesa
    • , Timothy Chou
    • , Arthur Chow
    • , Yogesh Saletore
    • , Matthew MacKay
    • , Jessica Schulman
    • , Christopher Famulare
    • , Minal Patel
    • , Virginia M Klimek
    • , Francine E Garrett-Bakelman
    • , Ari Melnick
    • , Martin Carroll
    • , Christopher E Mason
    • , Samie R Jaffrey
    •  & Michael G Kharas
  • Reviews |

    CD36 has important roles in lipid homeostasis, metabolic inflammation, reprogramming of energy metabolism, apoptosis and kidney fibrosis. Here, the authors discuss these roles as well as the regulation and post-translational modification of CD36 and its potential as a biomarker and a therapeutic target for kidney disease.

    • Xiaochun Yang
    • , Daryl M. Okamura
    • , Xifeng Lu
    • , Yaxi Chen
    • , John Moorhead
    • , Zac Varghese
    •  & Xiong Z. Ruan

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