Biotechnology

Definition

Biotechnology is a broad discipline in which biological processes, organisms, cells or cellular components are exploited to develop new technologies. New tools and products developed by biotechnologists are useful in research, agriculture, industry and the clinic.

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Latest Research and Reviews

  • Research | | open

    Most bacteria live in biofilms, surface-attached communities encased in an extracellular matrix. Here, Yan et al. show that matrix production in Vibrio cholerae increases the osmotic pressure within the biofilm, promoting biofilm expansion and physical exclusion of non-matrix producing cheaters.

    • Jing Yan
    • , Carey D. Nadell
    • , Howard A. Stone
    • , Ned S. Wingreen
    •  & Bonnie L. Bassler
  • Research | | open

    Screening libraries of genetically engineered microbes for secreted products is limited by the available assay throughput. Here the authors combine aptamer-based fluorescent detection with droplet microfluidics to achieve high throughput screening of yeast strains engineered for enhanced tyrosine or streptavidin production.

    • Joseph Abatemarco
    • , Maen F. Sarhan
    • , James M. Wagner
    • , Jyun-Liang Lin
    • , Leqian Liu
    • , Wafa Hassouneh
    • , Shuo-Fu Yuan
    • , Hal S. Alper
    •  & Adam R. Abate
  • Research |

    An atlas of microRNA expression patterns and regulators is produced by deep sequencing of short RNAs in human and mouse cells.

    • Derek de Rie
    • , Imad Abugessaisa
    • , Tanvir Alam
    • , Erik Arner
    • , Peter Arner
    • , Haitham Ashoor
    • , Gaby Åström
    • , Magda Babina
    • , Nicolas Bertin
    • , A Maxwell Burroughs
    • , Ailsa J Carlisle
    • , Carsten O Daub
    • , Michael Detmar
    • , Ruslan Deviatiiarov
    • , Alexandre Fort
    • , Claudia Gebhard
    • , Daniel Goldowitz
    • , Sven Guhl
    • , Thomas J Ha
    • , Jayson Harshbarger
    • , Akira Hasegawa
    • , Kosuke Hashimoto
    • , Meenhard Herlyn
    • , Peter Heutink
    • , Kelly J Hitchens
    • , Chung Chau Hon
    • , Edward Huang
    • , Yuri Ishizu
    • , Chieko Kai
    • , Takeya Kasukawa
    • , Peter Klinken
    • , Timo Lassmann
    • , Charles-Henri Lecellier
    • , Weonju Lee
    • , Marina Lizio
    • , Vsevolod Makeev
    • , Anthony Mathelier
    • , Yulia A Medvedeva
    • , Niklas Mejhert
    • , Christopher J Mungall
    • , Shohei Noma
    • , Mitsuhiro Ohshima
    • , Mariko Okada-Hatakeyama
    • , Helena Persson
    • , Patrizia Rizzu
    • , Filip Roudnicky
    • , Pål Sætrom
    • , Hiroki Sato
    • , Jessica Severin
    • , Jay W Shin
    • , Rolf K Swoboda
    • , Hiroshi Tarui
    • , Hiroo Toyoda
    • , Kristoffer Vitting-Seerup
    • , Louise Winteringham
    • , Yoko Yamaguchi
    • , Kayoko Yasuzawa
    • , Misako Yoneda
    • , Noriko Yumoto
    • , Susan Zabierowski
    • , Peter G Zhang
    • , Christine A Wells
    • , Kim M Summers
    • , Hideya Kawaji
    • , Albin Sandelin
    • , Michael Rehli
    • , The FANTOM Consortium
    • , Yoshihide Hayashizaki
    • , Piero Carninci
    • , Alistair R R Forrest
    •  & Michiel J L de Hoon
  • Research |

    The statistical concepts for false discovery rate control long applied in the field of data-dependent acquisition (DDA) mass spectrometry-based proteomics can be adapted for the emerging technique of data-independent acquisition (DIA) mass spectrometry.

    • George Rosenberger
    • , Isabell Bludau
    • , Uwe Schmitt
    • , Moritz Heusel
    • , Christie L Hunter
    • , Yansheng Liu
    • , Michael J MacCoss
    • , Brendan X MacLean
    • , Alexey I Nesvizhskii
    • , Patrick G A Pedrioli
    • , Lukas Reiter
    • , Hannes L Röst
    • , Stephen Tate
    • , Ying S Ting
    • , Ben C Collins
    •  & Ruedi Aebersold
  • Research |

    Paz Polak, Jaegil Kim, Lior Z. Braunstein and colleagues have identified patterns of genome-wide mutation in certain breast cancers that can be used to identify those with DNA-repair deficiencies that make the tumor more likely to respond to therapies based on PARP inhibitors or platinum. In contrast, oncogenic mutations in several other DNA-repair genes do not generate these patterns.

    • Paz Polak
    • , Jaegil Kim
    • , Lior Z Braunstein
    • , Rosa Karlic
    • , Nicholas J Haradhavala
    • , Grace Tiao
    • , Daniel Rosebrock
    • , Dimitri Livitz
    • , Kirsten Kübler
    • , Kent W Mouw
    • , Atanas Kamburov
    • , Yosef E Maruvka
    • , Ignaty Leshchiner
    • , Eric S Lander
    • , Todd R Golub
    • , Aviad Zick
    • , Alexandre Orthwein
    • , Michael S Lawrence
    • , Rajbir N Batra
    • , Carlos Caldas
    • , Daniel A Haber
    • , Peter W Laird
    • , Hui Shen
    • , Leif W Ellisen
    • , Alan D D'Andrea
    • , Stephen J Chanock
    • , William D Foulkes
    •  & Gad Getz
  • Research |

    Monocle 2 uses reversed graph embedding to automatically learn complex, branched pseudotime trajectories of differentiation or cellular state changes from single-cell expression data.

    Monocle 2 uses reversed graph embedding to automatically learn complex, branched pseudotime trajectories of differentiation or cellular state changes from single-cell expression data.

    • Xiaojie Qiu
    • , Qi Mao
    • , Ying Tang
    • , Li Wang
    • , Raghav Chawla
    • , Hannah A Pliner
    •  & Cole Trapnell

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